Intracellular DNA sensing by neutrophils and amplification of the innate immune response

As the first responders, neutrophils lead innate immune response to infectious pathogens and inflammation inducing agents. The well-established pathogen neutralizing strategies employed by are phagocytosis, action of microbicide granules, production ROS, secretion neutrophil extracellular traps (NETs). Only recently, ability sense respond pathogen-associated molecular patterns is being appreciated. This review brings together current information about intracellular recognition DNA proposes models signal amplification in response. Finally, clinical relevance sensing non-infectious diseases including malignancy also discussed.